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What Is Happening Physiologically Semaglutide activates GLP 1 receptors in the brain that regulate appetite and satiety
doi: 10.1186/s13098-025-01903-5, 27
When weight loss occurs quickly, facial fat that provides structure and volume diminishes faster than skin can adapt, [4] resulting in: A hollowed appearance, particularly in the cheeks Changes in lip , cheek, and chin dimensions Increased visibility of facial wrinkles An overall aged appearance Interestingly, recent research suggests GLP-1 agonists might affect adipose (fat) tissue dynamics in ways that could contribute to accelerated ageing beyond just weight loss
Clinical evidence suggests that tolerance to GLP-1 glucose-lowering effects does not develop in humans, despite occurring in animal models
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