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Reddy Laboratories, grants from Novartis, grants and personal fees from PCORI, grants from Scion, grants and personal fees from Teva, grants from Zosano, personal fees from Promius, personal fees from Biohaven, personal fees from Theranica, and grants from Satsuma, outside the submitted work

4 Future challenges 4.1 Mechanistic validation across ocular pathologies Despite progress in understanding molecular pathways such as calcium channel modulation and mitochondrial mitophagy, the relative contributions of these mechanisms to specific diseases remain unclear

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