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Published July 12, 2021

Presented for research literature review only Clayton AH et al

Some people lose significant thigh fat during GLP-1 treatment, particularly those on higher doses of tirzepatide or retatrutide , which can reduce the suitability of this site over time

Foreseeability Eli Lilly should have anticipated gastroparesis risk because: The same mechanism (slowed gastric emptying) was known from GLP-1 drugs Tirzepatides dual action might amplify this effect Clinical trial data should have been scrutinized for GI complications 2

Storage requirements differ between unreconstituted and reconstituted peptide