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If you are curious about what those first weeks feel like, the initial experience on semaglutide varies considerably from person to person, though most people notice appetite suppression within the first one to two weeks

The combination of delayed gastric emptying, enhanced insulin secretion, and reduced hepatic glucose production created more stable blood sugar patterns after eating

Indeed, a meta-analysis suggested that GLP-1 agonists may improve weight loss and insulin resistance in obese/overweight women than metformin does (234)

In the Phase 2 trial, participants at 48 weeks had not reached a plateau