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Studies show that people taking cagrilintide on its own have lost an average of 11 to 12% of their body weight over about 16 months

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58 BW was significantly reduced (up to 4.9% placebo-adjusted, p=0.013) over 4 weeks

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We found that 2A -adrenergic receptor activation by DA or NE results in G i1 recruitment to the receptor, with NE showing higher potency (EC 50 = 520 1.4 nM) and efficacy compared to DA (EC 50 = 2.1 0.002 M