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However, it may cause gastrointestinal side effects, including: Even though L-arginine supplements have a strong safety profile, its best to limit or avoid taking them if: youre pregnant or nursing have kidney disease, low blood pressure, or guanidinoacetate methyltransferase deficiency have recently had a heart attack are going to have surgery in 2 weeks or more Consider speaking with a healthcare professional before taking L-arginine supplements

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PMID 40353578

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Other recognised side effects include injection site reactions (redness, itching, or bruising), headache, dizziness, and fatigue