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Some individuals may require more frequent injections, while others might benefit from less frequent doses

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We look at who should take B12 injections, how quickly your body starts using them, and how long the effects last

The mutation in ALDH4A1 leads to the accumulation of pyrroline-5-carboxylate (P5C) in the mitochondria, which can react with PLP to cause PLP deficiency in the brain and can also be converted to proline, resulting in elevated plasma proline levels (Fig

People with this condition need lifelong vitamin B12 replacement therapy