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Proceedings of the National Academy of Sciences of the United States of America, 94 (5), 1967

This discovery also exemplifies a broader principle in cell biology: the critical importance of metabolite and nutrient trafficking across organelle membranes in regulating cellular function and health

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Estrogens also signal through membrane-bound receptors (e.g., GPER1 and palmitoylated-ER variants) to initiate non-genomic signaling, and these pathways often intersect and cross-regulate each other (145148)