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(2011) reported a down-regulation of SRIF in the dorsolateral prefrontal cortex (PFC), the subgenual cingulate cortices (Tripp et al., 2011), and the amygdala (Guilloux et al., 2011) of MDD patients

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These findings suggest that the source of tyrosinase can influence the optimal binding mode of arbutin, indicating that arbutin may have two preferred binding orientations

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