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At the end of 72 weeks, the change in the ratio of total fat mass to lean mass was 0.24 for tirzepatide versus 0.06 for placebo, indicating a greater improvement with tirzepatide [67]
Interestingly, research has shown that even in animals lacking beta-3 adrenergic receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting additional metabolic pathways may be involved beyond the primary beta-3 receptor mechanism
A good metabolism leads to a decrease in body fat and an increase in lean muscle mass
RAMD, random acceleration molecular dynamics
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