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Benefits of GLP-1 and GIP Treatment Clinically Proven Results : Many patients lose 10-15% or more of their body weight

Wojtyczka, R

These sections were stained with either hematoxylin and eosin (H&E) or picrosirius red with a fast green counterstain

However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists

These observations, combined with our findings of enhanced ATP signalling in the presence of Exendin-4 in the human DRG neurons, and by others in rodent neurons [31], suggest that GLP-1R may participate in modulating gut motility, rather than pain signalling