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GLP-1 is a gut-derived hormone secreted in response to oral nutrient intake, exhibiting potent insulinotropic activity across several species, including humans [8]

Front Cell Dev Biol 2020;8:602574.ArticlePubMedPMC 38

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Researchers divided participants equally among three groups receiving either retatrutide 9 mg, retatrutide 12 mg or placebo, administered as a once-weekly injection alongside healthy diet and physical activity recommendations