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The enzymes affected belong to one of three categories: Very long-chain acyl-CoA dehydrogenase (VLCAD): The symptoms that result from deficiencies in VLCAD were originally ascribed to loss of long-chain acyl-CoA dehydrogenase (LCAD) activity
The FDA is also reviewing nerandomilast for the treatment of PPF with a decision anticipated in early January 2026
References Rivas S, Pandya AG
Sweetwyne et al., 2017
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