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The recommendation to combine GHK-Cu and retinol is mechanistically rational, but honest framing requires acknowledging that it is based on mechanistic reasoning and tolerability data rather than a direct clinical trial of the combination

This GSH concentration decline was related with the reduced expression of proteins involved in GSH synthesis

10.1016/j.biopha.2022.112917 48 WisemanR

In fact, LXR agonists up-regulate the expression of both ABCA1 and ABCG1 in macrophages which leads to increased reverse cholesterol transport

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