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Acknowledgements The study is supported by a Singapore EDB-IPP grant (grant number: RL2012035)

350 A global lactylome and proteome analysis profiling of a hepatitis B virus-related HCC cohort identified 9256 non-histone and 19 histone protein lactylation sites in tumors and adjacent livers, demonstrating the ubiquitous nature of lactylation in tumor biology beyond histones and transcriptional regulation