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Because these stimulated neurons represent a distinct population from POMC neurons, as indicated by a lack of co-localization, there may be a neuronal population aside from POMC cells in the arcuate nucleus (ARN) of the hypothalamus that is stimulated only by GLP-1 and GIP administration, the characteristics of which are still unknown (24)

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When engaging with GHRH receptors located in regions like the pituitary and hypothalamus, it is theorized that Tesamorelin may stimulate the secretion of HGH from the resident pituitary cells