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These results, while promising, require confirmation in the ongoing Phase 3 programme before any conclusions about comparative efficacy can be drawn

Rip1 autophosphorylation is promoted by mitochondrial ros and is essential for rip3 recruitment into necrosome

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For the first three mice, immediately following DMRS data collection, we took blood from the hearts to perform in vitro 2H-NMR with an 18.8 T nuclear magnetic resonance facility (800 MHz NMR) to validate our results recorded at a lower spectral resolution