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Vitamin B is often given as a standalone injection when needed, because B has a large molecular size and specific storage dynamics
The provider will decide the dose, injection site, and schedule
Subcutaneous injections can be less painful and easier to do yourself
In a 23-week trial, subjects taking 1mg daily lost an average of 2.8kg compared to 0.8kg for placebo
Two downstream consequences are mechanistically central: nicotinamide is preserved for re-entry into the NAD+ salvage pathway (raising intracellular NAD+ availability), and SAM is preserved for other methylation reactions
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