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The overall incidence of adverse events was similar between the two treatments, but with numerically fewer adverse events leading to discontinuation with lixisenatide (10.4% vs
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[14] [4] Vomiting, especially if persistent or containing blood or material resembling coffee grounds, requires urgent assessment
B.RizkallaG.WangH.et al (1999)
And when combined with semaglutide in the CagriSema combination , those GI numbers climbed even further, with 79.6% of participants experiencing some form of gastrointestinal event
Facing pressure from generics after semaglutides patent expired on March 20, 2026, Novo Nordisk cut prices by 36% effective April 1, 2026 bringing the 0.25 mg weekly shot down to 1,415 (about 5,660/month)
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