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GLP-1 fatigue is a well-documented side effect that tends to worsen during periods of dosing instability
Each treatment option comes with its own advantages and disadvantages, so it is worth understanding the options available and discussing them with your doctor in order to tailor a treatment protocol that works for you
To see how these compare, let's look at the data from different trials
Whilst day-to-day hypoglycaemia was not coded in our network, we employed hypoglycaemia requiring hospital admission as a surrogate outcome of severe hypoglycaemia and there was no difference in the incidence in our cohort compared to the general population with type 1 diabetes
Additionally, while some of these side effects may theoretically influence hormonal balance, there is limited scientific evidence directly linking semaglutide use to menstrual irregularities
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