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For example, the ingestion of trimethylamine-containing (TMA-containing) dietary nutrients enriched in animal products such as choline, phosphatidylcholine, and l-carnitine can serve as precursor for the ultimate generation of an atherogenic metabolite, trimethylamine N -oxide (TMAO), via a metaorganismal pathway involving initial gut microbial formation of TMA, followed by host hepatic conversion of TMA into TMAO (48)
Clinical Effectiveness: SURMOUNT-1 Trial (Tirzepatide 15 mg): Duration: 72 weeks Participants: 2,539 adults with obesity Average Weight Loss: 22.5% of body weight 10 mg Dose: 21.4% weight loss 5 mg Dose: 15.0% weight loss Placebo: 2.4% weight loss 5% Weight Loss: 96% of participants 10% Weight Loss: 89% of participants 15% Weight Loss: 78% of participants 20% Weight Loss: 63% of participants This is the best weight loss result ever achieved with medication in clinical trials
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