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FIGURE 12 4.1.1 Imidazo[1,2-a] pyrazine derivatives An HTS campaign and subsequent structural optimization of Compound 37 , an initially identified PDE10A inhibitor, led to the discovery of imidazo[1,2-a] pyrazine-containing Compound 40 , a potent and selective PDE10A inhibitor exhibiting promising in vivo efficacy across various rodent behavioral models of schizophrenia, along with favorable pharmacokinetic properties in rats

It also plays a vital role in the bodys natural detoxification processes, helping to process and eliminate environmental toxins

At $0.067 per mg, the 1500mg vial offers strong per-milligram value for a high-concentration antioxidant compound

Three or four vials for Phase 3 and Phase 4 gets expensive and wasteful since each vial has solution remaining after the last needed draw

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