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Global Fortification Data Exchange
These in vitro studies in monolayers with cancer-derived cell lines differ radically from the situation in vivo in the normal intact intestinal epithelium with numerous specialized cell types, intact blood and lymphatic circulations, and other structures and factors such as the glycocalyx, secreted mucus, reticuloendothelial cells, other immune cells, and mesenteric nerves
These results support a useful selectivity window for NNMT research, but they were obtained with a limited panel of related enzymes and do not rule out every possible off-target interaction
Altered mitochondrial dynamics may not simply be a passive consequence of aging but rather an adaptive mechanism designed to mitigate cellular damage associated with aging, which could serve as a potential target for extending lifespan and promoting healthy aging
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