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Personally, I find Michael Pollans words my guiding principle which should be applicable to healthy living generally : Eat (Real) Food

Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, et al

After 8 weeks of SSRI treatment, the plasma concentration of several metabolites from different classes changed significantly, for example, among the acylcarnitines, an increased level of three short-chain acylcarnitines, and a decrease in medium and long-chain acylcarnitines were observed

and Jain et al

Additionally, the body needs sufficient stomach acid for the digestion process to absorb vitamin B12 effectively