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GLP-1 medications work on appetite and blood sugar regulation but do not directly compromise blood cell counts, clotting factors, or immune function in ways that would contaminate the blood supply
Large-scale clinical trials, including the SELECT cardiovascular outcome trial with over 17,000 participants, have not demonstrated increased overall cancer incidence with these medications compared to placebo groups
The PIONEER series of clinical trials, called Peptide Innovation for Early Diabetes Treatment, aimed to establish the clinical role of oral semaglutide
10.1093/ehjcvp/pvad072 74
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