The amyloidogenic core sequence of hIAPP (residues 2029, known as the FGAILS region) has been substituted to eliminate -sheet aggregation propensitya critical requirement for generating a stable, injectable research compound
It is a structural component of many transcription factors and DNA repair enzymes, including p53, AP-1, and polymerases
Symptoms such as fatigue, mood changes, difficulty concentrating and pins-and-needles sensations in the hands and feet can all point to low vitamin B12 levels
Research suggests that the peptide may help improve the function of joints, particularly in cases where cartilage damage has occurred
Despite reports of cell Golgi stress and dysregulation of Golgi-associated genes in T1D, as well as the role of the Golgi in class I HLA hypo-expression following CVB infection, the effects of CVB infection on islet Golgi integrity are poorly studied (138, 158, 246)