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137,138 ERS Continuous insulin production and secretion in cells under chronic hyperglycemia and IR result in the overload of protein folding machinery and the accumulation of excessive misfolded or unfolded proteins in the ER, therefore triggering UPR and the ERS

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The researchers hypothesized the potential action of the AHK-Cu copper peptide complexes on collagen formation by attempting to isolate the quantity of collagen type I produced by fibroblasts in a cell culture