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Clinicians should guide their patients through the benefits and limitations of each to ensure safe and informed decisions

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It produces hormones that dysregulate appetite, increase cortisol sensitivity, and impair growth hormone secretion

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He noted that most significant savings would happen at a starting BMI of around 40, but added that those savings still may not be great enough to pay for the current list price of these drugs. Cawley said there are numerous other reasons to cover the drug, though, such as improving someones quality of life