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Methylcobalamin is one of the biologically active forms of B12
It combines three amino acids: cysteine, glutamic acid, and glycine
[2] Pharmacokinetic studies demonstrate rapid systemic distribution with peak plasma levels occurring within 30-60 minutes of intramuscular injection, followed by extensive hepatic storage and enterohepatic recycling
92,121 To date, more than 190 mutations in PKLR have been reported to be associated with pyruvate kinase deficiency (www.pklrmutationdatabase.com)
In other patients with vitamin B12 deficiency, the duration of therapy and route of administration will depend upon the cause and whether or not it is reversible
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