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As described above, eccDNAs carrying single or multiple copies of advantageous eccCDSs may spread through tissues and across generations (Zhang et al., 2024), thereby expanding the genetic landscape accessible to populations

It also shifts the balance from eumelanin (dark pigment) to pheomelanin (lighter pigment) , leading to a naturally brighter, more even skin tone

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation