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This observation also raised some concerns about the potential adverse effect of GLP-1 RAs on the risk of incident cardiac arrhythmias
Discussion Due to the central roles exerted by the three metabolically related peptide hormone receptors (GIPR, GLP-1R and GCGR) in the management of T2DM and obesity, the concept of combinatorial agonism or polypharmacology to synergize metabolic actions and maximize therapeutic benefits has been explored in the past decade with remarkable preclinical and clinical achievements
It helps protect the body from damage caused by disease and aging
Mechanistically, semaglutide works on the GLP-1 hormone system to reduce appetite and slow digestion, while tesofensine works on brain neurotransmitter reuptake
Women using GLP-1 medications frequently reported menstrual irregularities, including changes in cycle timing and flow
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