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The 13-amino acid extension (Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn) does more than add length

This impairs capillary integrity, allowing peripheral iron, lymphocytes, and cytokines to infiltrate the brain parenchyma, thereby amplifying local inflammation and iron dysregulation ( Moreover, ferroptosis-associated damage molecules such as high mobility group box-1 (HMGB1) and chemokine CXCL2 can directly impair the functional stability of brain microvascular endothelial cells

These phenolics found in UDE could exert an antioxidative protective effect against H 2 O 2 -induced oxidative stress and neuroinflammation

H., Cheon, J

Sintesi endogena e distribuzione tissutale In assenza di alterazioni genetiche o patologie, l'organismo in grado di produrre carnitina: circa 1,2 mol/die/kg , pari complessivamente a circa il 25% della carnitina totale