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Not manufactured with milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten

Comparability of baseline characteristics with SOUL trial participants ( N = 9,650) is summarised in (Supplementary Table 2)

& Sakai, R

11 Elevated cortisol can negatively impact metabolism, promote fat storage (especially abdominal fat), disrupt other hormones involved in appetite regulation, increase cravings (particularly for high-sugar, high-fat foods), and contribute to insulin resistance, potentially hindering weight loss efforts despite medication and diet changes