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Infect is a mechanic that does this pretty well, but you can also use spells such as target creature gets -2/-2 until end of turn or something similar

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I post these guys here not as personal preference but because the OCG decks have often seen use with these guys in Trains

(Choose any number of cards in your hand, on top of your library, or on the battlefield under your control

Actions that can be negated include card and effect activations, Summons, and attacks